The antagonist protocol combines Clomid with a GnRH antagonist, like Cetrotide or Ganirelix. This approach helps prevent premature ovulation, allowing for more precise control of follicle growth.
Clomid stimulates the ovaries to produce multiple follicles. However, sometimes these follicles mature too quickly. The GnRH antagonist prevents this premature surge of luteinizing hormone (LH), which triggers ovulation.
Doctors typically start Clomid administration on cycle day 3 or 5. Monitoring with ultrasound scans and blood tests closely tracks follicle development. Once follicles reach a desired size (typically around 14-16mm), the GnRH antagonist is added. This usually happens for several days until the trigger shot of hCG is given, followed by egg retrieval.
This precise timing is key to the success of the antagonist protocol. It minimizes the risk of premature LH surge and maximizes the chances of retrieving mature eggs suitable for fertilization.
The antagonist protocol is often favored over other protocols due to its flexibility and potential to reduce the risk of ovarian hyperstimulation syndrome (OHSS). However, it does require more frequent monitoring appointments.
Important Note: The antagonist protocol is a complex fertility treatment. A reproductive endocrinologist will personalize the protocol to each patient’s needs, considering factors such as age, ovarian reserve, and medical history. Always discuss potential benefits and risks thoroughly with your physician before beginning treatment.
