Clarithromycin ER, while effective, can cause side effects. Common ones include nausea, diarrhea, vomiting, and abdominal pain. Less common but more serious reactions exist; seek immediate medical attention if you experience severe allergic reactions (such as swelling, difficulty breathing, or hives), irregular heartbeat, or jaundice (yellowing of skin or eyes).
Common Side Effects
- Nausea Diarrhea Vomiting Abdominal pain Taste disturbances Headache Dizziness
These usually resolve on their own, but inform your doctor if they persist or worsen.
Serious Side Effects – Seek Immediate Medical Attention
- Severe allergic reactions (anaphylaxis) Irregular heartbeat (arrhythmias) Jaundice (yellowing of skin and eyes) Dark urine Clay-colored stools Unusual fatigue
Potential Drug Interactions
Clarithromycin ER interacts with many medications. This list is not exhaustive; always inform your doctor and pharmacist of all medications you take.
Drugs that increase Clarithromycin levels (leading to increased side effects):
- Statins (e. g., atorvastatin, simvastatin) Ergotamine derivatives Pimozide Cisapride Certain antihistamines
Drugs whose effects may be altered by Clarithromycin:
Warfarin (increased bleeding risk) Theophylline (increased levels) Digoxin (increased levels) Cyclosporine (increased levels)
This information is for general knowledge and does not substitute for professional medical advice. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.


