Renagel, containing sevelamer hydrochloride, lowers serum phosphorus levels by binding phosphate in the gastrointestinal tract. It’s a non-absorbable polymer that prevents phosphate absorption, effectively removing it from the body through excretion. This binding action is crucial for managing hyperphosphatemia, a common complication of chronic kidney disease (CKD).
Dosage Guidelines
Dosage is individualized based on serum phosphorus levels and patient response. Typically, treatment starts with 800 mg three times daily with meals. Dosage adjustments are made to maintain target phosphorus levels. Doses can range from 800mg to 3200 mg daily, administered in divided doses with meals. Always follow your doctor’s specific instructions. Regular monitoring of serum phosphorus levels is necessary to ensure optimal treatment and adjust the dosage accordingly. Remember, consistent adherence to the prescribed regimen is key for effective phosphate control.
Potential Interactions
Sevelamer can affect the absorption of other medications, including some vitamins and minerals. Your doctor will consider these interactions when prescribing Renagel. Always inform your physician about all medications you are taking, including over-the-counter drugs and supplements.


