Always inform your doctor about all medications, supplements, and herbal remedies you’re taking, including over-the-counter drugs. This includes prescription and non-prescription medications.
Medications that may increase the risk of side effects:
- Sedatives and hypnotics: Combining Zyprexa with benzodiazepines (like diazepam or alprazolam) or other sedatives can significantly increase drowsiness and sedation. Opioids: Concurrent use with opioid pain medications can heighten the risk of respiratory depression. Monitor your breathing carefully. Antihypertensives: Zyprexa may potentiate the hypotensive effects of certain blood pressure medications. Regular blood pressure monitoring is recommended. Lithium: Concurrent use with lithium can increase the risk of neurotoxicity, requiring close monitoring of blood levels of both medications. Other antipsychotics: Combining Zyprexa with other antipsychotics might lead to additive side effects, particularly those related to movement disorders.
Medications that may affect Zyprexa’s metabolism:
Strong CYP3A4 inhibitors: Medications that inhibit the CYP3A4 enzyme (like ketoconazole or ritonavir) can increase Zyprexa blood levels, potentially intensifying side effects. Your doctor might adjust your Zyprexa dosage. Strong CYP3A4 inducers: Conversely, medications that induce CYP3A4 (like rifampin or carbamazepine) might reduce Zyprexa’s effectiveness. Dosage adjustments are often necessary.
This list isn’t exhaustive. Always consult your physician or pharmacist for a complete evaluation of potential drug interactions before starting or changing any medication. They can provide personalized advice based on your health status and medication profile. Report any new or worsening side effects immediately.
