Sildenafil should not be used by individuals with certain health conditions. Avoid it if you have a history of heart attack or stroke within the last six months, uncontrolled high blood pressure, low blood pressure, or unstable angina.
Similarly, avoid sildenafil if you have inherited retinal diseases like retinitis pigmentosa or if you have a known allergy to sildenafil or any of its components.
Taking sildenafil with certain medications can lead to dangerous interactions. Significant interactions occur with nitrates (used to treat angina). Combining these medications can cause a significant drop in blood pressure, potentially leading to fainting or even heart attack.
Sildenafil also interacts with other medications, including alpha-blockers (used to treat high blood pressure and prostate problems), certain antifungals (like ketoconazole and itraconazole), and HIV protease inhibitors (like ritonavir and indinavir). These interactions may intensify the blood pressure-lowering effects of sildenafil or prolong its effects.
Always inform your doctor about all medications, supplements, and herbal remedies you are currently taking. This includes over-the-counter drugs. Your doctor can assess potential risks and provide tailored advice.
| Nitrates | Nitroglycerin, isosorbide mononitrate | Severe hypotension |
| Alpha-blockers | Terazosin, doxazosin | Hypotension |
| Antifungals (Azole Class) | Ketoconazole, itraconazole | Increased sildenafil levels |
| HIV Protease Inhibitors | Ritonavir, indinavir | Increased sildenafil levels |
This information is not exhaustive. Consult your physician or pharmacist for a complete list of contraindications and potential drug interactions before using sildenafil.
