Consult your doctor immediately if you experience seizures, allergic reactions (rash, swelling, difficulty breathing), or severe skin reactions (Stevens-Johnson syndrome). Common side effects include headache, dry mouth, nausea, constipation, and insomnia. These usually lessen over time, but inform your doctor if they persist or worsen.
Interactions with Other Medications
Wellbutrin XL interacts with several medications. Avoid combining it with MAO inhibitors (like phenelzine or tranylcypromine) due to a serious risk of serotonin syndrome. Concurrent use with other medications that increase serotonin levels (like SSRIs or SNRIs) requires careful monitoring by your physician. It can also interact with certain seizure medications, blood thinners, and some antibiotics. Always inform your doctor and pharmacist of all medications, supplements, and herbal remedies you are taking before starting Wellbutrin XL, to avoid potentially dangerous interactions. This includes over-the-counter drugs.
Other Potential Side Effects
Less common but still possible side effects include tremors, dizziness, changes in appetite or weight, increased heart rate, and anxiety. Changes in mood, including increased irritability or agitation, should also be reported. While rare, there’s a possibility of developing increased suicidal thoughts. Regular check-ups with your doctor allow them to monitor your progress and address any concerns promptly. Open communication is vital for safe medication use.


