Sildenafil primarily treats erectile dysfunction (ED) in men. It achieves this by inhibiting phosphodiesterase-5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP).
Increased cGMP levels relax the smooth muscles in the penis, allowing increased blood flow. This engorgement is necessary for an erection. The medication facilitates this process, improving erectile function.
| Phosphodiesterase-5 (PDE5) | Breaks down cGMP | Inhibits PDE5, increasing cGMP levels |
| CGMP | Relaxes penile smooth muscles | Higher levels promote blood flow to the penis |
Importantly, sexual stimulation remains necessary; sildenafil doesn’t create erections spontaneously. It simply enhances the body’s natural response to sexual arousal.
Dosage varies depending on individual needs and physician recommendations. Always consult a doctor before using sildenafil or any medication for ED.
