Before starting Metformin ER 1000, inform your doctor about any existing health conditions. This includes kidney disease (check your eGFR), liver disease, heart failure, or a history of lactic acidosis. Severe infections, dehydration, or alcohol consumption can increase the risk of lactic acidosis, a serious complication. Avoid alcohol while taking this medication.
Kidney Function
Regular monitoring of kidney function is crucial, especially at the start of treatment and periodically thereafter. Your doctor will likely order blood tests to assess your eGFR. Dose adjustments or discontinuation might be necessary if kidney function declines.
B12 Deficiency
Long-term use of Metformin can sometimes lead to vitamin B12 deficiency. Regular blood tests to monitor vitamin B12 levels are recommended, and supplementation might be necessary. Symptoms of B12 deficiency include fatigue, weakness, and neurological problems.
Other Precautions
Inform your doctor about all medications you are taking, including over-the-counter drugs and supplements, as interactions can occur. Be aware of potential gastrointestinal side effects such as nausea, diarrhea, and vomiting, which usually subside after a few days. If side effects persist or worsen, contact your healthcare provider. During surgery or medical procedures requiring anesthesia, temporary discontinuation might be necessary. Always discuss this with your doctor.
Contraindications
Metformin ER 1000 is contraindicated in patients with: severe kidney disease, severe liver disease, acute or chronic metabolic acidosis, and acute myocardial infarction. Individuals with a history of lactic acidosis should also avoid Metformin.
