Domperidone primarily affects dopamine receptors in the brain and gastrointestinal tract. It selectively blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) in the brain, preventing nausea and vomiting.
Simultaneously, domperidone increases the motility of the upper gastrointestinal tract. This means it speeds up the movement of food through the stomach and into the small intestine. This action promotes gastric emptying and relieves symptoms associated with slow digestion.
The mechanism isn’t fully understood, but it’s believed to involve the modulation of several neurotransmitters and hormones impacting gut function. It does not significantly cross the blood-brain barrier, minimizing central nervous system side effects compared to other antiemetic drugs.
| Reduces Nausea & Vomiting | Blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) |
| Increases Gastric Motility | Enhances upper gastrointestinal tract muscle contractions |
This dual action makes domperidone useful for treating various conditions, including nausea, vomiting, and gastroparesis. Always consult a doctor before using domperidone, as it’s crucial to determine the correct dosage and suitability for your individual health circumstances.
