Always inform your doctor and pharmacist of all medications, supplements, and herbal remedies you are taking before starting Diflucan (fluconazole). This includes prescription drugs, over-the-counter medications, and even vitamins. Some medications can significantly affect how Diflucan works, or vice versa. For example, Diflucan can increase the blood levels of certain medications like warfarin (a blood thinner), leading to increased risk of bleeding. Therefore, close monitoring of your INR (International Normalized Ratio) is necessary if you’re on warfarin.
Specific Medication Interactions
Diflucan interacts with several classes of medications, including:
- Anticoagulants: As mentioned, warfarin levels can rise. Oral hypoglycemics: Diflucon can affect blood sugar levels in patients taking medications like sulfonylureas or metformin. Certain anti-seizure medications: Interactions with phenytoin and carbamazepine are possible, potentially altering the effectiveness of these drugs. Certain statins: The risk of myopathy (muscle damage) may increase when Diflucan is combined with some statins, such as simvastatin. Pimozide: This interaction can cause a serious heart rhythm problem.
This list isn’t exhaustive; consult your doctor or pharmacist for a complete list of potential interactions.
Substances to Avoid
Alcohol consumption while taking Diflucan can worsen side effects like nausea and vomiting. You should minimize or avoid alcohol entirely during treatment. Similarly, grapefruit juice can interact with Diflucan, potentially increasing its levels in the body. Avoid excessive grapefruit juice consumption.
